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Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Castellano BM, et al. Among authors: van eijkeren rj. Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417. Science. 2017. PMID: 28336668 Free PMC article.
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells.
Engelen SE, Ververs FA, Markovska A, Lagerholm BC, Kraaijenhof JM, Yousif LI, Zurke YX, Gulersonmez CM, Kooijman S, Goddard M, van Eijkeren RJ, Jervis PJ, Besra GS, Haitjema S, Asselbergs FW, Kalkhoven E, Ploegh HL, Boes M, Cerundolo V, Hovingh GK, Salio M, Stigter EC, Rensen PC, Monaco C, Schipper HS. Engelen SE, et al. Among authors: van eijkeren rj. JCI Insight. 2023 May 8;8(9):e158089. doi: 10.1172/jci.insight.158089. JCI Insight. 2023. PMID: 36976644 Free PMC article.
Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation.
Rakhshandehroo M, van Eijkeren RJ, Gabriel TL, de Haar C, Gijzel SMW, Hamers N, Ferraz MJ, Aerts JMFG, Schipper HS, van Eijk M, Boes M, Kalkhoven E. Rakhshandehroo M, et al. Among authors: van eijkeren rj. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167. doi: 10.1016/j.bbalip.2019.04.016. Epub 2019 Apr 30. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31051284 Free article.